A study performed at Tel Aviv University shows that hyperbaric oxygen treatments may alleviate symptoms experienced by patients with Alzheimer’s Disease.
The research was conducted by PhD student Ronit Shapira of TAU’s Faculty of Life Sciences; Prof. Beka Solomon and Dan Frenkel of TAU’s Sagol School of Neuroscience and Faculty of Life Sciences; and Prof. Shai Efrati of TAU’s Sackler Faculty of Medicine, Sagol School of Neuroscience and Assaf-Harofeh Medical Center. It was published in the journal Neurobiology of Aging.
Patients who undergo hyperbaric oxygen therapy for different conditions breathe in pure oxygen in a pressurized room or chamber. In this chamber, the air pressure is increased to twice that of normal air. Under these conditions, oxygen solubility in the blood increases and is transported by blood vessels throughout the body. The added oxygen stimulates the release of growth factors and stem cells, which themselves promote healing.
The TAU scientists used a mouse model of Alzheimer’s disease and built a custom-made hyperbaric oxygen chamber suitable for small animals. Then, over the course of 14 days, the team administered hyperbaric oxygen treatment to the mice for one hour per day. After 14 days, the mice underwent a series of behavioral tests as well as tissue biochemical tests to understand how hyperbaric oxygen treatment affects the pathological hallmarks associated with Alzheimer’s disease.
The treatment reduced behavioral deficiencies compared to the non-transgenic control mice, reduced plaque pathology by 40%, and reduced neuroinflammation by about 40%.
Read the full article on Science Daily